Publications

 

□2009            □2008   □2007    □2006    □2005    □2004    □2003    □2002    □2001    □2000    □1999    □1998    □1997    □1996    □1995

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AiF-Projects

 

 

 

 

 

 

 

 

 

 

 

 

Publications

 

2009

 

[172]  CiF Award - Feierlicher Rahmen für Hamburger Absolventen
Interview zur Preisverleihung mit Prof. Dr. Markus Fischer
Deutsche Lebensmittelrundschau, 12/2009 28-30 (2009)
 

[171]    Lebensmittelanalytik

4., vollständig überarbeitete Auflage

R. Matissek, S. Steiner and M. Fischer

ISBN 978-3-540-92204-9

Springer Dordrecht Heidelberg london New York  (2009)

 

Lebensmittelanalytik, Klappe die Vierte
Interview zum Buch mit Prof. Dr. Reinhard Matissek
Deutsche Lebensmittelrundschau, 9/2009 28-30 (2009)

 

[170]    Genetic analysis for the non-expression of O157 antigen in an O rough:H7 Escherichia coli strain

L. V. Rump, P. C. H. Feng, M. Fischer AND S. R. Monday

Appl. Environ. Microbiol. doi:10.1128/AEM.02046-09 (in press) (2009)

 

[169]    Trends in der Lebensmittelanalytik: DNA-basierte Wege zur Identifizierung von Gewürzen

F. Focke, I. Haase and M. Fischer

Nachrichten aus der Chemie, 57, 1017-1020 (2009)

 

[168]    Discovery and Development of the Covalent Hydrates of Trifluoromethylated Pyrazoles as Riboflavin Synthase Inhibitors with Antibiotic Activity Against Mycobacterium tuberculosis.

Y. Zhao, A. Bacher, B. Illarionov, M. Fischer, G. Georg, OZ Ye, PE Fanwick,  SG Franzblau, B. Wan and M. Cushman

J. Org. Chem. 74(15):5297-303 (2009)

 

[167]    Discovery and Development of a Small Molecule Library with Lumazine Synthase Inhibitory Activity

A. Talukdar, M. Breen, A. Bacher, B. Illarionov, M. Fischer, G. Georg,¶ Q.-Z. Ye and M. Cushman

J. Org. Chem.  74(15):5123-34  (2009)

 

[166]    Tryptophan 13C nuclear-spin polarization generated by intraprotein electron transfer in a LOV2 domain of the blue-light receptor phototropin.

W. Eisenreich, M. Fischer, W. Römisch-Margl, M.  Joshi,  G. Richter, A. Bacher and S. Weber

Biochem Soc Trans., 37(Pt 2):382-6 (2009)

 

[165]    Biosynthesis of coenzymes

I. Haase, M. Fischer, A. Bacher, W. Eisenreich and F. Rohdich

In: Cofactor biosynthesis. Wiley Encyclopedia of Chemical Biology, 393-407 (2009)

 

[164]   Biosynthesis of riboflavin

M. Fischer and A. Bacher

In: Escherichia coli and Salmonella (in press) (2009)

 

[163]   Cofactors: The Biosynthesis of Folate and Pterin and their Enzymology
M.Fischer, B. Thöny and S. Leimkühler
In: Comprehensive Natural Products Chemistry II (in press) (2009)

[162]   Cofactors: Cofactors: The Biosynthesis of Riboflavin

M.Fischer and A. Bacher
In: Comprehensive Natural Products Chemistry II (in press) (2009)
 

 

 

 

2008

 

[161]    15N{31P} REDOR NMR Studies of the binding of phosphonate reaction intermediate analogues to Saccharomyces cerevisiae lumazine synthase

T.-Y. Yu, R. D. O'Connor, A. C. Sivertsen, C. Chiauzzi, B. Poliks, M. Fischer, A. Bacher, I. Haase, M. Cushman and J. Schaefer

Biochemistry 47(52):13942-51 (2008)

 

[160]    Natural Abundance Solution 13C NMR Studies of a Phototropin with Enhanced Polarization

W. Eisenreich, M. Joshi, S. Weber, A. Bacher and M. Fischer

J. Am. Chem. Soc. 130(41):13544-5 (2008)

 

[159]    A novel solid phase technology for high-throughput gene synthesis

J. Van den Brulle, M. Fischer, T. Langmann, G. Horn, T. Waldmann, S. Arnold, M. Fuhrmann, O. Schatz, T. O´Connell, D. O´Connell, A. Auckenthaler and H. Schwer

BioTechniques, 45(3), 432-35 (2008)

 

[158]    Biosynthesis of riboflavin. 2,5-Diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthases of fungi and archaea

W. Roemisch-Margl, W. Eisenreich, I. Haase, A. Bacher and M. Fischer

FEBS J., 275(17):4403-14 (2008)

 

[157]    Improvement of the quality of lumazine synthase crystals by protein engineering

L. Rodríguez-Fernández, F. J. López-Jaramillo, A. Bacher, M. Fischer and S. Weinkauf

Acta Cryst., 64(Pt 7), 625-8 (2008)

 

[156]    Structure of lumazine protein, an optical transponder of luminescent bacteria

L. Chatwell, V. Illarionova, B. Illarionov, W. Eisenreich, R. Huber, A. Skerra, A. Bacher and M. Fischer

J. Mol. Biol., 382(1), 44-55 (2008)

 

[155]    What is the yellow of the egg?

M. Fischer und A. Bacher

Biospektrum  14(3), 236-239 (2008)

 

[154]    A new series of N-[2,4-dioxo-6-D-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid derivatives as inhibitors of lumazine synthase and riboflavin synthase: Design, synthesis, biochemical evaluation, crystallography, and mechanistic implications

Y. Zhang, B. Illarionov, E. Morgunova, G. Jin, A. Bacher, M. Fischer,  R. Ladenstein, and M. Cushman

J. Org. Chem. 73(7):2715-2724. (2008)

 

[153]    Biosynthesis of Vitamin B2: Structure and mechanism of riboflavin synthase

M. Fischer and Adelbert Bacher

Arch. Biochem. Biophys., 474(2), 252-65 (2008)

 

[152]    State-of-the-art Methoden der Lipidanalytik

N. Hinrichsen and M. Fischer

GIT Labor-Fachzeitschrift 3/2008 (in press) (2008)

 

[151]    Klassische Methoden der Fettanalytik

N. Hinrichsen and M. Fischer

GIT Labor-Fachzeitschrift 2/2008, 106-109 (2008)

 

 

 

2007

 

[150]    Molecular biological methods for quality analysis of foods. Forschung fuer den Wettbewerb von Morgen: Aktuelle Beitraege aus FEI-Projekten

M. Fischer and I. Haase

Dokumentation der FEI-Jahrestagung, 65th, Freising-Weihenstephan, Germany, Sept. 5-6, 2007 (2007)

 

[149]    Differenzierung von Theobroma cacao und Theobroma grandiflorum mittels PCR

I. Haase and M. Fischer

J.Con. Prot. and Food Safety (in press) (2007)

 

[148]    Synthesis and Enzyme Inhibitory Activity of the S-Nucleoside Analogue of the Ribitylaminopyrimidine Substrate of Lumazine Synthase and Product of Riboflavin Synthase

A. Talukdar, B. Illarionov, A. Bacher, M. Fischer and M. Cushman

J. Org. Chem., 72 (19), 7167 -7175 (2007)

 

[147]    13C Isotopologue editing of FMN bound to phototropin domains

W. Eisenreich, M. Joshi, B. Illarionov, G. Richter, W. Römisch-Margl, F. Müller, A. Bacher and M. Fischer

FEBS J. (in press) (2007)

 

[146]    Structural and kinetic properties of Lumazine synthase isoenzymes in the order Rhizobiales.

S. Klinke, V. Zylberman, H. R. Bonomi, I. Haase, B. G. Guimarães, B. C. Braden, A. Bacher, M. Fischer, F. A. Goldbaum

J. Mol. Biol. (in press) (2007)

 

[145]    Analyse von Lebensmittelallergenen

A. Paschke and M. Fischer

GIT  Labor-Fachzeitschrift (in press) (2007)

 

[144]    Lumazine proteins from Photobacterium. Localization of the single ligand binding site to the N-terminal domain

B. Illarionov, W. Eisenreich, M. Wirth, C. Y. Lee, Y. E. Woo, A. Bacher, and M. Fischer

Biol. Chem. (in press) (2007)

 

[143]    A New Series of 3-Alkyl Phosphate Derivatives of 4,5,6,7-Tetrahydro-1-D-ribityl-1H-pyrazolo[3,4-d]pyrimidinedione as Inhibitors of Lumazine Synthase: Design, Synthesis and Evaluation

Y. Zhang, J. Jin, B. Illarionov, A. Bacher, M. Fischer and M. Cushman

J. Org. Chem., 72 (19), 7176 -7184 (2007)

 

[142]     Lumazine synthase from Candida albicans as an anti-fungal target enzyme: Structural and biochemical basis for drug design

E. Morgunova, S. Saller, I. Haase, M. Cushman, A. Bacher, M. Fischer and R. Ladenstein

J. Biol. Chem., 282(23), 17231-17241 (2007)

 

[141]     A High Throughput Screening Platform for Inhibitors of the Riboflavin Biosynthesis Pathway

J. Kaiser, B. Illarionov, F. Rohdich, W. Eisenreich, S. Saller, J. Van den Brulle, M. Cushman, A. Bacher and M. Fischer

Anal. Biochem. 365, 52–61(2007)

 

[140]     Frictional Drag and Electrical Manipulation of Recombinant Proteins in Polymer Supported Membranes 

M. Tanaka, J. Hermann,I. Haase, M. Fischer and S. G. Boxer

Langmuir (in press) (2007)

 

[139]     Fortschritte in der Entwicklung von Gensynthese-Strategien. Eine neuartige Methode

M. Fischer

GIT Labor-Fachzeitschrift 1/2007, 24-27 (2007)

 

[138]     A novel Lumazine Synthase Inhibitor Derived from Oxidation of 1,3,6,8-Tetrahdroxy-2,7-naphthyridine to a Tetraazaperylenehexaone Derivative

Y. Zhang, B. Illarionov, A. Bacher, M. Fischer, G.I. Georg, Qi-Z. Ye, D. Vander Velde, P.E. Fanwick, Y. Song, and M. Cushman

J. Org. Chem., 72 (8), 2769 -2776 (2007)

 

[137]     Ligand Binding Properties of the N-Terminal Domain of Riboflavin Synthase from Escherichia coli 

C.-Yong Lee, B. Illarionov, Y.-E. Woo, K. Kemter, R.-R. Kim, S. Eberhardt, M. Cushman, W. Eisenreich, M. Fischer and A. Bacher
J. Biochem. & Mol. Biol. (in press) (2007)
 

[136]     Yersinia  protein kinase YopO is activated by a novel G-Actin binding process

C. Trasak, G. Zenner, A. Vogel, G. Yüksekdag, R. Rost, I. Haase, M. Fischer, L. Israel, A. Imhof, S. Linder, M.  Schleicher, and M.  Aepfelbacher

J. Biol. Chem. 282(4), 2268-77 (2007)

 

 

2006


[135]     Moderne Lebensmittelanalytik unter die Lupe genommen. Einsatz spektroskopischer und chromatographischer Methoden

M. Bunzel und M. Fischer

GIT Labor-Fachzeitschrift 10/2006, 943 - 946 (2006)

 

[134]     Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis
E. Morgunova, B. Illarionov, G. Jin, I. Haase, A. Bacher, M. Cushman, M. Fischer and R. Ladenstein
FEBS J., 273, 4790-804 (2006)

[133]     Towards an identification of chemically different flavin radicals by means of their g-tensor
A. Schnegg, A. Okafuji, A. Bacher, R. Bittl, M. Fischer, M. Fuchs, P. Hegemann, M. Joshi, C.W.M. Kay, G. Richter, E. Schleicher and S. Weber
Appl. Magn. Res. (in press) (2006)
 

[132]     Non-mevalonate terpene biosynthesis enzymes as antiinfective drug targets. Substrate synthesis and high throughput screening methods

V. Illarionova, J. Kaiser, E. Ostrozhenkova, A. Bacher, M. Fischer, W. Eisenreich and F. Rohdich

J. Org. Chem., 71, 8824-8834 (2006)

 

[131]     Multiple assembly states of lumazine synthase- a model relating catalytic function and molecular assembly

X. Zhang, P. V. Konarev, M. V. Petoukhov, D. I. Svergun, L. Xing, H. R. Cheng, I. Haase, M. Fischer, A. Bacher, R. Ladenstein and W. Meining

J. Mol. Biol., 362, 753-70 (2006)

 

[130]     Molecular basis for the herbizide resistance of Roundup Ready crops

T. Funke, H. Han, M. L. Healy-Fried, M. Fischer and E. Schönbrunn

Proc. Natl. Acad. Sci. US, 103, 13010-5 (2006)

 

[129]     Cytoskeletal polymer networks: molecular structure of cross-linkers determine macrosopic properties

B. Wagner, R. Tharmann, I. Haase, M. Fischer and A.R. Bausch

Proc. Natl. Acad. Sci. US, 103, 13974-8 (2006)

 

[128]     Blue light-initiated DNA repair by photolyase

C. W. M. Kay, A. Bacher, M. Fischer, G. Richter, E. Schleicher and S. Weber

In: Flavins: Photochemistry and Photobiology (Silva E. & Edwards A.M.,, eds) pp 153-185. RCS Publishing, Cambridge, UK, 151-182 (2006)

 

[127]     Evolution of vitamin B2 biosynthesis. 6,7-dimethyl-8-ribityllumazine synthases of Brucella

V. Zylberman, S. Klinke, I. Haase, A. Bacher, M. Fischer and F. A. Goldbaum

J. Bacteriol. 188(17), 6135-42(2006)

 

[126]     Cloning, purification, crystallization and preliminary crystallographic analysis of SecA from Enterococcus faecalis

W. Meining, J. Scheuring, M. Fischer and S. Weinkauf

Acta Cryst. F, 62(Pt 6):583-5 (2006)

 

[125]     Biosynthesis of riboflavin. Structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5’-phosphate reductase of Methanocaldococcus jannaschii

L. Chatwell, T. Krojer, A. Fidler, W. Römisch, W. Eisenreich, A. Bacher, R. Huber and M. Fischer

J. Mol. Biol. 359(5), 1334-51 (2006)

 

[124]     Crystal structure of an archaeal pentameric riboflavin synthase in complex with a substrate analog inhibitor: Stereochemical implications

A. Ramsperger, M. Augustin, A.-K. Schott, S. Gerhardt, T. Krojer, W. Eisenreich, B. Illarionov, M. Cushman, A. Bacher, R. Huber and M. Fischer

J. Biol. Chem. 281(2), 1224-32 (2006)

 

[123]     Monomeric red fluorescent protein variants used for imaging studies in different species

A. Müller-Taubenberger, M. J. Vos, A. Böttger, M. Lasi, F. P. L. Lai, M. Fischer, K. Rottner

Eur. J. Cell Biol. 85(9-10), 1119-29 (2006)

 

[122]     Visualizing cytoskeleton dynamics in mammalian cells using a humanized variant of monomeric red fluorescent protein

M. Fischer, I. Haase, S. Wiesner, A. Müller-Taubenberger

FEBS Letters, 580(10),2495-502 (2006)

 

[121]     Coupling artificial actin cortices to biofunctionalized lipid monolayers

K. Sengupta, L. Limozin, M. Tristl, I. Haase, M. Fischer, E. Sackmann

Langmuir 22(13), 5776-5785 (2006)

 

[120]     Biosynthesis of Vitamin B2 in Plants

M. Fischer and A. Bacher

Phys. Plant., 126(3), 304-318 (2006)

 

[119]     Field Effect of Screened Charges: Electrical Detection of Peptides and Proteins by a Thin-Film Resistor (p NA)

S.Q. Lud, M.G. Nikolaides, I. Haase, M. Fischer and A.R. Bausch

ChemPhysChem 7(2), 379-384 (2006)

 

[118]     Evolution of a biosynthetic pathway – From lumazine synthases to riboflavin synthases

M. Fischer, W. Römisch, B. Illarionov, W. Eisenreich, A. Ramsperger, M. Augustin, R. Huber and A. Bacher

Chemistry & Biology of Pteridines & Folates (in press) (2006)

 

[117]     PCR in der Lebensmittelanalytik

M. Fischer and I. Haase

GIT Labor-Fachzeitschrift 3/06 (2006)

 

 

2005


[116]     Crystal structures of oxidized and reduced stellacyanin from horseradish roots.

M. Koch, M. Velarde, M.D. Harrison, S. Echt, M. Fischer, A. Messerschmidt, C. Dennison

J. Am. Chem. Soc., 127(1), 158-66 (2005)

 

[115]     The crystal structure of Lumazine Synthase from Mycobacterium tuberculosis as a target for rational drug design: Binding mode of a new class of purine trione inhibitors.

E. Morgunova, W. Meining, B. Illarionov, I. Haase, A. Bacher, Mark Cushman, M. Fischer and Rudolf Ladenstein

Biochemistry, 44(8), 2746-2758 (2005)

 

[114]     Presteady state kinetic analysis of riboflavin synthase using a pentacyclic reaction intermediate as substrate

B. Illarionov, I. Haase, M. Fischer, A. Bacher and N. Schramek

Biol. Chem.,  386(2), 127-136 (2005)

 

[113]     Fusion of an acetylcholine-binding protein to an ion channel stabilizes the chimeric receptor in a desensitized form. (La fusion d’une protéine liant l’acetylcholine à un canal ionique stabilise le récepteur chimérique dans une forme désensibilisée).

T. Grutter, L. P. de Carvalho, V. Dufresne, A. Taly, M. Fischer and J.-P. Changeux

Comptes Rendus Biologies, 328(3), 223-234 (2005)

 

[112]     A Metastable Prerequisite for the Growth of Lumazine Synthase Crystals

O. Gliko, N. Neumaier, W. Pan, M. Fischer, I. Haase, A. Bacher, S. Weinkauf and P. G. Vekilov

J. Am. Chem. Soc., 127(10), 3433-3438 (2005)

 

[111]     A high-throughput screen utilizing the fluorescence of riboflavin for identification of lumazine synthase inhibitors

J. Chen, B. Illarionov, A. Bacher, M. Fischer, G. Georg, Q. Ye and M. Cushman

Anal. Biochem., 338,124–130 (2005)

 

[110]     The biosynthetic pathway of vitamin B2 as place of attack for new antimicrobial substances

M. Fischer

GIT Labor-Fachzeitschrift 3/2005 (2005)

 

[109]     Biosynthesis of Flavocoenzymes

M. Fischer and A. Bacher

Nat. Prod. Rep., 22(3), 324-350 (2005)

Cover page:

 

[108]     Structures and reaction mechanisms of riboflavin synthases from eubacterial and archaeal origin

M. Fischer, W. Römisch, B. Illarionov, W. Eisenreich and A. Bacher

Biochem. Soc. Trans., 33(4), 780-784 (2005)

 

[107]     Protein-Engineering: Der Weg zu einem neuartigen fluoreszierenden Protein
M. Fischer
GIT Labor-Fachzeitschrift 9/2005 (in press) (2005)
 

[106]     Evolution of vitamin B2 biosynthesis. Riboflavin synthase of A. thaliana and its inhibition by riboflavin

M. Fischer, I. Haase, R. Feicht, N. Schramek, P. Köhler, P. Schieberle and A. Bacher

Biol. Chem., 386(5), 417-28 (2005)

 

[105]     Biosynthesis of Vitamin B2. Diastereomeric reaction intermediates of archaeal and non-archaeal riboflavin synthases.

B. Illarionov, W. Eisenreich, N. Schramek, A. Bacher and M. Fischer

J. Biol. Chem., 280, 28541-28546 (2005)

 

[104]     Design, synthesis, and biochemical evaluation of 1,5,6,7-tetrahydro-6,7-dioxo-9-D-ribitylaminolumazines bearing alkyl phosphate substituents as inhibitors of lumazine synthase and riboflavin synthase
M. Cushman, G. Jin, B. Illarionov, M. Fischer, R. Ladenstein and A. Bacher
J. Org. Chem., 70(20), 8162-70 (2005)
 

[103]     Wirkstoffsuche: Der Biosyntheseweg von Vitamin B2 als Angriffsort für neuartige antimikrobielle Wirkstoffe

M. Fischer

Lebensmittelchemie, 59, 96-97 (2005)

 

[102]     Random isotopolog libraries for protein perturbation studies. 13C NMR studies on lumazine protein of Photobacterium leiognathi 

B. Illarionov, C. Y. Lee, A. Bacher, M. Fischer and W. Eisenreich

J. Org. Chem., 70(24), 9947-54 (2005)

 

[101]     Photochemically induced dynamic nuclear polarization in a C450A mutant of the LOV2 domain of the Avena sativa blue-light receptor phototropin

G. Richter, S. Weber, W. Römisch, A. Bacher, M. Fischer, and W. Eisenreich

J. Am. Chem. Soc., 127(49):17245-52 (2005)

 

[100]     Biotechnologische Wege zu Vitaminen: Der erste Schritt der Biosynthese von Folsäure in Pflanzen und Mikroorganismen

M. Fischer

Lebensmittelchemie, 59, 15 (2005)

 

[99]     Photocycle of a blue light receptor LOV2 domain reconstituted with 5-deaza-FMN

S. Hecht, G. Richter, A. Bacher, M. Joshi, W. Römisch, G. Greiner, R. Frank, S. Weber, W. Eisenreich and M. Fischer

Flavins and Flavoproteins 2005, Proceedings of the International Symposium, 15th, Shonan Village Center, Hayama, Japan, April 17 - 22, 2005 (T. Nishino, R. Miura, M. Tanokura, F. Fukui, eds.), 569-574 (2005)

 

[98]     Studies of the Photocycle of the Blue-Light Receptor Phototropin. Observation of Nuclear-Spin Polarization by Solution 13C-NMR

G. Richter, A. Bacher, S. Weber, W. Römisch, M. Joshi, M. Fischer and W. Eisenreich

Flavins and Flavoproteins 2005, Proceedings of the International Symposium, 15th, Shonan Village Center, Hayama, Japan, April 17 - 22, 2005 (T. Nishino, R. Miura, M. Tanokura, F. Fukui, eds.), 587-591 (2005)

 

[97]     Lumazine protein from Photobacterium leiognathi. Localization of the single ligand binding site

B. Illarionov, W. Eisenreich, M. Wirth, Y.-E. Woo, C. Y. Lee and M. Fischer

Flavins and Flavoproteins 2005, Proceedings of the International Symposium, 15th, Shonan Village Center, Hayama, Japan, April 17 - 22, 2005 (T. Nishino, R. Miura, M. Tanokura, F. Fukui, eds.), 643-648 (2005)

 

[96]     Evolution of riboflavin biosynthesis: Structures and reaction mechanisms of riboflavin synthases from eubacterial and archaeal kingdom

M. Fischer, B. Illarionov, W. Römisch, A. Bacher and W. Eisenreich

Flavins and Flavoproteins 2005, Proceedings of the International Symposium, 15th, Shonan Village Center, Hayama, Japan, April 17 - 22, 2005 (T. Nishino, R. Miura, M. Tanokura, F. Fukui, eds.), 713-723 (2005)

 

[95]     Biosynthesis of Riboflavin. Stereochemistry and structure of 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5’-phosphate synthase of Methanococcus jannaschii

M. Fischer, L. Chatwell, W.Römisch, W. Eisenreich, R. Huber, T. Krojer and A. Bacher

Flavins and Flavoproteins 2005, Proceedings of the International Symposium, 15th, Shonan Village Center, Hayama, Japan, April 17 - 22, 2005 (T. Nishino, R. Miura, M. Tanokura, F. Fukui, eds.), 725-730 (2005)

 

[94]     Vitamin B2 biosynthesis in plants. The pyrimidine deaminase and the riboflavin synthase of Arabidopsis thaliana

M. Fischer, W. Roemisch, I. Haase, R. Feicht, N. Schramek, P. Koehler, P. Schieberle, S. Saller, B. Illarionov, W. Eisenreich and A. Bacher

Flavins and Flavoproteins 2005, Proceedings of the International Symposium, 15th, Shonan Village Center, Hayama, Japan, April 17 - 22, 2005 (T. Nishino, R. Miura, M. Tanokura, F. Fukui, eds.), 731-736 (2005)

 

[93]     Stable isotope labeled flavocoenzymes as probes for flavoprotein spectroscopy: Preparation and use of random and ordered libraries

W. Römisch, B. Illarionov, G. Richter, A. Bacher, M. Fischer and W. Eisenreich

Flavins and Flavoproteins 2005, Proceedings of the International Symposium, 15th, Shonan Village Center, Hayama, Japan, April 17 - 22, 2005 (T. Nishino, R. Miura, M. Tanokura, F. Fukui, eds.), 743-747 (2005)

 

[92]     Potential antiinfective targets in pathogenic yeasts. GTP cyclohydrolase II and 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans

M. Fischer, S. Echt, S. Bauer, S. Steinbacher, R. Huber, S. Kraut, W. Roemisch, W. Eisenreich, I. Haase and A. Bacher

Flavins and Flavoproteins 2005, Proceedings of the International Symposium, 15th, Shonan Village Center, Hayama,  Japan, April 17 - 22, 2005 (T. Nishino, R. Miura, M. Tanokura, F. Fukui, eds.), 889-894 (2005)

 

 

2004


[91]     Design, Synthesis, and Evaluation of 9-D-Ribitylamino-1,3,7-trihydro-2,6,8-purinetriones Bearing Alkyl Phosphate and alpha,alpha-Difluorophosphonate Substituents as Inhibitors of Riboflavin Synthase and Lumazine Synthase
M. Cushman, T. Sambaiah, G. Jin, B. Illiaronov, M. Fischer and A. Bacher
J. Org. Chem., 69(3), 601-12 (2004)
[90]     Molecular biological methods of food analysis 
M. Fischer
Nachrichten aus der Chemie, 52(3), 309-312. (2004)
[89]     Folate Biosynthesis in Higher Plants: cDNA Cloning, Heterologous Expression, and Characterization of Dihydroneopterin Aldolases
A. Goyer, V. Illarionova, S. Roje, M. Fischer, A. Bacher and A. D. Hanson
 Plant Physiol., 135(1), 103-11 (2004)
[88]     Biosynthesis of tetrahydrofolate in plants. Crystal structure of 7,8-dihydroneopterin aldolase from Arabidopsis thaliana
S. Bauer, A.-K. Schott, V. Illarionova, A. Bacher, R. Huber and M. Fischer
J. Mol. Biol. 339(4), 967-79 (2004)
[87]     Crystal structure of the molybdenum cofactor biosynthesis protein MoaB of Escherichia coli
G. Bader, M. Gomez-Ortiz, C. Haussmann, A. Bacher, R. Huber and M. Fischer
Acta Crystallogr. D Biol. Crystallogr. 60(Pt 6), 1068-75 (2004)
Cover page

[86]     Metamorphosis of an Enzyme
R. Ladenstein, W. Meining, X. Zhang, M. Fischer, and A. Bacher
Conformational Proteomics of macromolecular Architecture: Approaching the Structure of large macromolecular Assemblies and their Mechanisms of Action (Cheng H & Hammar L, eds) pp 198-221. World Scientific Pub. Co. Stockholm (2004)
[85]     Biotechnologische Wege zu Vitaminen: Die Biosynthese von Riboflavin
M. Fischer
LVT Lebensmittel Industrie 5/6, GIT Verlag Mai 2004, 48-50 (2004)
[84]     Rapid preparation of isotopolog libraries by biotransformation in vivo. Studies on the riboflavin precursor, 6,7-dimethyl-8-ribityllumazine
B. Illarionov, M. Fischer, C. Y. Lee, A. Bacher and W. Eisenreich
J Org Chem., 69(17):5588-94 (2004)
[83]     Structural basis of Charge Transfer Complex Formation by Riboflavin bound to 6,7-Dimethyl-8-ribityllumazine Synthase
M. Koch, C. Breithaupt, S. Gerhardt, I. Haase, S. Weber, M. Cushman, R. Huber, A. Bacher and M. Fischer
 Eur. J. Biochem., 271(15):3208-14 (2004)
[82]     Potential antiinfective targets in pathogenic yeasts. 3,4-Dihydroxy-2-Butanone-4-Phosphate Synthase of Candida albicans
S. Echt, S. Bauer, R. Huber, A. Bacher and M. Fischer
 J. Mol. Biol., 341(4),1085-96 (2004)
[81]     Metal sites in 3,4-Dihydroxy-2-Butanone-4-Phosphate Synthase of Methanococcus jannaschii in complex with the substrate ribulose 5-phosphate
S. Steinbacher, S. Schiffmann, A. Bacher and M. Fischer
 Acta Crystallogr. D Biol. Crystallogr., 60(Pt 7):1338-40 (2004)
[80]     Evolution of vitamin B2 biosynthesis. Structural and functional similarity between pyrimidine deaminases of eubacterial and plant origin
M. Fischer, W. Römisch, S. Saller, B. Illarionov, G. Richter, W. Eisenreich and A. Bacher
 J. Biol. Chem., 279(35), 36299-308 (2004)
[79]     The Photo-Induced Triplet State of Flavins. Probing the Reaction Mechanism of Adduct Formation in LOV Domains of the Plant Blue-Light Receptor Phototropin 
E. Schleicher, R. M. Kowalczyk, C. W.M. Kay, P. Hegemann, A. Bacher, M. Fischer, R. Bittl, G. Richter and S. Weber
 J. Am. Chem. Soc., 126(35),11067-11076 (2004)
[78]     Design, Synthesis, and Evaluation of Acyclic C-Nucleoside and N-Methylated Derivatives of the Ribitylaminopyrimidine Substrate of Lumazine Synthase as Potential Enzyme Inhibitors and Mechanistic Probes
J. Chen, T. Sambaiah, B. Illarionov, M. Fischer, A. Bacher and M. Cushman
 J. Org. Chem., 69(21), 6996-7003 (2004)
[77]     Evolution of vitamin B2 biosynthesis. A novel class of riboflavin synthase in Archaea
M. Fischer, A.-K. Schott, W. Römisch, A. Ramsperger, M. Augustin, A. Fidler, A. Bacher, G. Richter, R. Huber and W. Eisenreich
 J. Mol. Biol., 343(1),267-78 (2004)
[76]     A brilliant version of monomeric RFP used to visualize actin cytoskeleton dynamics in Dictyostelium
M. Fischer, I. Haase, E. Simmeth, G. Gerisch, and A. Müller-Taubenberger
 FEBS Letters 577(1-2), 227-32(2004)

 

follow-up article:

Biophotonics International (February 2005): Fluorescent protein research shines brilliantly. Red fluorescent protein allows dual-wavelength microscopy

 

[75]     Molekularbiologie und Lebensmittelchemie - Eine Verbindung mit Zukunft (Editorial)

M. Fischer

GIT Laborzeitschrift, November 2004, 977 (2004)

 

 

2003


[74]     Mimicking Tissue Surfaces by Supported Membrane Coupled Ultrathin Layer of Hyaluronic Acid
K. Sengupta, J. Schilling, S. Marx, M. Fischer, A. Bacher and E. Sackmann
 Langmuir, 19(5), 1775-1781 (2003)

[73]     Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I
J. Rebelo, G. Auerbach, G. Bader, A. Bracher, H. Nar, C. Hösl, N. Schramek, J. Kaiser, A. Bacher, R. Huber and M. Fischer
 J. Mol. Biol., 326(2), 503–516 (2003)
[72]     Enzyme catalysis via control of activation entropy. Site directed mutagenesis of 6,7-dimethyl-8-ribityllumazine synthase
M. Fischer, I. Haase, K. Kis, W. Meining, R. Ladenstein, M. Cushman, N. Schramek, R. Huber and A. Bacher
 J. Mol. Biol., 326(3), 783-793 (2003)
[71]     Crystal structure of riboflavin kinase of Schizosaccharomyces pombe
S. Bauer, K. Kemter, R. Feicht, R. Huber, A. Bacher, M. Fischer and S. Steinbacher
 J. Mol. Biol., 326(5), 1463-1473 (2003)
[70]     Biosynthesis of riboflavin in Archaea: 6,7-Dimethyl-8-ribityllumazine synthase of Methanococcus jannaschii
I. Haase, S. Mörtl, P. Köhler, A. Bacher and M. Fischer
 Eur. J. Biochem., 270(5), 1025-1032 (2003)
[69]     A structure-based model of the reaction catalysed by lumazine synthase from Aquifex aeolicus
X. Zhang, W. Meining, I. Haase, M. Fischer, A. Bacher and R. Ladenstein
 J. Mol. Biol., 328(1), 167-182 (2003)
[68]     Blue Light Perception in Plants. EPR and ENDOR Detection of a Light-Induced Neutral Flavin Radical in a C450A Mutant of Phototropin
C. W. M. Kay, A.S Kuppig, E. Schleicher, H. Hofner, W. Rüdiger, M. Schleicher, M. Fischer, A. Bacher, S. Weber and G. Richter
 J. Biol. Chem., 278(13):10973-10982 (2003)
[67]     Biosynthesis of riboflavin. Single turnover kinetic analysis of 6,7-dimethyl-8-ribityl-lumazine synthase
N. Schramek, I. Haase, M. Fischer and A. Bacher
 J. Am. Chem. Soc., 125(15), 4460-4466 (2003)
[66]     Structure and properties of an engineered transketolase from maize
S. Gerhardt, S. Echt, M. Busch, J. Freigang, G. Auerbach, G. Bader, R. Huber, A. Bacher and M. Fischer
 Plant Physiol., Vol. 132, 1941-1949 (2003)
[65]     Temperature dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus.
I. Haase, M. Fischer, A. Bacher and N. Schramek
 J. Biol. Chem., 278(39), 37909-37915.(2003)
[64]     Structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with divalent metal ions and the substrate ribulose 5-phosphate. Implications for the catalytic mechanism
S. Steinbacher, S. Schiffmann, G. Richter, R. Huber, A. Bacher and M. Fischer
 J. Biol. Chem., 278(43), 42256-42265 (2003)
[63]     Presteady state kinetic analysis of riboflavin synthase
B. Illarionov, I. Haase, A. Bacher, M. Fischer and N. Schramek
 J. Biol. Chem., 278(48), 47700-47706 (2003)
 

[62]     Riboflavin synthase of Schizosaccharomyces pombe. Protein Dynamics revealed by 19F NMR Protein Perturbation experiments
M. Fischer, A.-K. Schott, K. Kemter, R. Feicht, G. Richter, B. Illarionov, W. Eisenreich, S. Gerhardt, M. Cushman, R. Huber and A. Bacher
 BMC Biochemistry, 4(1), 18. (2003)

 

[61]     Biosynthesis of Riboflavin: Presteady State Kinetics of Lumazine Synthase
I. Haase, M. Fischer, A. Bacher and N. Schramek
13th International Conference on Pterins, Folates, and Related Biogenic Amines, Maui, USA (2003)
[60]     Biosynthesis of Riboflavin: The Structural Basis of Riboflavin Binding to 6,7-Dimethyl-8-ribityllumazine Synthase from Schizosaccharomyces pombe
M. Fischer, S. Gerhardt, I. Haase, M. Cushman, R. Huber and A. Bacher
13th International Conference on Pterins, Folates, and Related Biogenic Amines, Maui, USA (2003)

 

 

2002


[59]     Localization of two enzymes of the tetrahydrobiopterin biosynthetic pathway in embryonic chick retina
V. Holdengreber, C. Krieger, M. Gütlich, N. Schramek, M. Vechoropoulos, M. Fischer, A. Bacher and Y. Ben-Shaul
 J. Histochem. Cytochem., 50(2), 265-274 (2002)
[58]     Biosynthesis of riboflavin. 6,7-Dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe
M. Fischer, I. Haase, R. Feicht, G. Richter, S. Gerhardt, J.-P. Changeux, R. Huber, and A. Bacher
 Eur. J. Biochem., 269(2), 519-526 (2002)

[57]     Reaction mechanism of GTP cyclohydrolase I. Single turnover experiments using a kinetically competent reaction intermediate
N. Schramek, A. Bracher, M. Fischer, G. Auerbach, H. Nar, R. Huber and A. Bacher
 J. Mol. Biol., 316(3), 827-835 (2002)

[56]     Investigation of the binding of epimer A of the covalent hydrate of 6,7-bis(trifluoromethyl)-8-D-ribityllumazine to a recombinant F22W Bacillus subtilis lumazine synthase mutant by 15N{19F}REDOR NMR
A. K. Mehta, D. R. Studelska, M. Fischer, A. Gießauf, K. Kemter, A. Bacher, M. Cushman and J. Schaefer
 J. Org. Chem., 67(7), 2087-2092 (2002).
[55]     The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase
S. Gerhardt, I. Haase, J. Kaiser, R. Huber, A. Bacher and M. Fischer
 J. Mol. Biol., 318(5), 1317-1329 (2002)
[54]     Formation of metal nanoclusters on specific surface sites of protein molecules
N. Braun, W. Meining, U. Hars, M. Fischer, R. Ladenstein, R. Huber, A. Bacher, S. Weinkauf and L. Bachmann
 J. Mol. Biol., 321(2), 341-53 (2002)

[53]     Biosynthesis of tetrahydrofolate. Stereochemistry of dihydroneopterin aldolase
V. Illarionova, W. Eisenreich, M. Fischer, C. Haußmann, W. Römisch, G. Richter and A. Bacher
 J. Biol. Chem., 277(32), 28841-7 (2002)

[52]     Design, synthesis, and evaluation of 6-carboxyalkyl and 6-Phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and lumazine synthase
M. Cushman, D. Yang, S. Gerhardt, R. Huber, M. Fischer, K. Kis and A. Bacher
 J. Org. Chem., 67(16), 5807-16 (2002)
[51]     Biosynthesis of riboflavin in Archaea. 3,4-Dihydroxy-2-butanone 4-phosphate synthase of Methanococcus jannaschii
M. Fischer, W. Römisch,S. Schiffmann, S. Steinbacher, W. Eisenreich, G. Richter and A. Bacher
 J. Biol. Chem., 277(44), 41410-6 (2002)
[50]     Folate synthesis in plants: The first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase I
G. Basset, E.P. Quinlivan, M.J. Ziemak, R. Diaz de la Garza, M. Fischer, S. Schiffmann, A. Bacher, J.F. Gregory and A.D. Hanson
 Proc. Natl. Acad. Sci. USA, 99(19), 12489-94 (2002)
[49]     Incorporation of an Amide into 5-Phosphonoalkyl-6-D-ribitylaminopyrimidinedione Lumazine synthase Inhibitors results in an unexpected reversal of selectivity for riboflavin synthase vs. lumazine synthase
M. Cushman, D. Yang, J. T. Mihalic, S. Gerhardt, R. Huber, M. Fischer, K. Kis and A. Bacher
 J Org Chem. 67(20), 6871-7 (2002)
[48]     Studies on the Reaction Mechanism of Riboflavin Synthase. X-ray Crystal Structure of a Complex with 6-Carboxyethyl-7-oxo-8-ribityllumazine
S. Gerhardt, A.-K. Schott, N. Kairies, M. Cushman, B. Illarionov, W. Eisenreich, A. Bacher, R. Huber, S. Steinbacher and M. Fischer*
 Structure (Camb)., 10(10), 1371-81 (2002)

 

[47]     Studies on the reaction mechanism of GTP cyclohydrolase I
N. Schramek, A. Bracher, G. Bader, M. Fischer, G. Auerbach, M. Gütlich, W. Eisenreich, R. Huber and A. Bacher
Chemistry and Biology of Pteridines and Folates, Proceedings of the International Symposium on Pteridines and Folates, 12th, Bethesda, MD, United States, June 17-22, 2001 (2002)
[46]     NMR studies on the mechanism of the blue light receptor phototropin from Avena sativa
G. Richter, W. Römisch, E. Schleicher, M. Fischer, A. Bacher, W. Eisenreich, M. Salomon, E. Knieb, H. Dürr, W. Rüdiger, V. Massey, F. Müller and S. Weber
Flavins and Flavoproteins 2002, Proceedings of the International Symposium, 14th, Cambridge, United Kingdom, July 14-18, 2002 (Chapman, S., Perham, R., Scrutton, N., eds.), 719-724 (2002)

[45]     Single Turnover Kinetic Analysis of 6,7-Dimethyl-8-ribitylumazine Synthase from Bacillus subtilis
N. Schramek, I. Haase, M. Fischer and A. Bacher
Flavins and Flavoproteins 2002, Proceedings of the International Symposium, 14th, Cambridge, United Kingdom, July 14-18, 2002 (Chapman, S., Perham, R., Scrutton, N., eds.), 363-368 (2002)

[44]     Biosynthesis of Riboflavin: 6,7-Dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe and its unusual affinity to riboflavin
I. Haase, R. Feicht, G. Richter, A. Bacher, M. Fischer, S. Gerhardt, R. Huber and J.-P. Changeux
Flavins and Flavoproteins 2002, Proceedings of the International Symposium, 14th, Cambridge, United Kingdom, July 14-18, 2002 (Chapman, S., Perham, R., Scrutton, N., eds.), 199-204 (2002)

[43]     Single Turnover Kinetic Analysis of Riboflavin Synthase from Escherichia coli
B. Illarionov, I. Haase, W. Eisenreich, M. Fischer, A. Bacher and N. Schramek
Flavins and Flavoproteins 2002, Proceedings of the International Symposium, 14th, Cambridge, United Kingdom, July 14-18, 2002 (Chapman, S., Perham, R., Scrutton, N., eds.), 223-228 (2002)

[42]     Essential Zinc Ions at the Catalytic Sites of GTP Cyclohydrolases
J. Kaiser, N. Schramek, S. Püttmer, M. Schuster, S. Eberhardt, J. Rebelo, G. Auerbach, G. Bader, A. Bracher, H. Nar, C. Hösl, M. Fischer, R. Huber and A. Bacher
Flavins and Flavoproteins 2002, Proceedings of the International Symposium, 14th, Cambridge, United Kingdom, July 14-18, 2002 (Chapman, S., Perham, R., Scrutton, N., eds.), 241-246 (2002)

[41]     19F NMR ligand perturbation studies on the Riboflavin synthase of Schizosaccharomyces pombe
M. Fischer, A.-K. Schott, K. Kemter, R. Feicht, G. Richter, B. Illarionov, W. Eisenreich, S. Gerhardt, S. Steinbacher, R. Huber, M. Cushman and A. Bacher
Flavins and Flavoproteins 2002, Proceedings of the International Symposium, 14th, Cambridge, United Kingdom, July 14-18, 2002 (Chapman, S., Perham, R., Scrutton, N., eds.), 161-166 (2002)

[40]     Studies on the Mechanism of 3,4-Dihydroxy-2-butanone 4-phosphate Synthase of the Archaeon Methanococcus jannaschii
M. Fischer, W. Römisch, S. Schiffmann, W. Eisenreich, G. Richter, S. Steinbacher, R. Huber, H. Oschkinat, M. Kelly and A. Bacher
Flavins and Flavoproteins 2002, Proceedings of the International Symposium, 14th, Cambridge, United Kingdom, July 14-18, 2002 (Chapman, S., Perham, R., Scrutton, N., eds.), 167-173 (2002)

[39]     The Biosynthesis of Flavocoenzymes: Crystal structure of Schizosaccharomyces pombe riboflavin kinase
S. Bauer, R. Huber, S. Steinbacher, K. Kemter, A. Bacher and M. Fischer
Flavins and Flavoproteins 2002, Proceedings of the International Symposium, 14th, Cambridge, United Kingdom, July 14-18, 2002 (Chapman, S., Perham, R., Scrutton, N., eds.), 33-38 (2002)
[38]     The Crystal Structure of Riboflavin Synthase of Schizosaccharomyces pombe in Complex with 6-Carboxyethyl-7-oxo-8-ribityllumazine reveals insights into the Reaction Mechanism
S. Gerhardt, S. Steinbacher, N. Kairies, R. Huber, A.K. Schott, B. Illarionov, W. Eisenreich, A. Bacher, M. Fischer and M. Cushman
Flavins and Flavoproteins 2002, Proceedings of the International Symposium, 14th, Cambridge, United Kingdom, July 14-18, 2002 (Chapman, S., Perham, R., Scrutton, N., eds.), 45-50 (2002)

[37]     The crystal structure of lumazine synthase from Schizosaccharomyces pombe
S. Gerhardt, S. Steinbacher, J.T. Kaiser, R. Huber, I. Haase, A. Bacher, M. Fischer and M. Cushman
Flavins and Flavoproteins 2002, Proceedings of the International Symposium, 14th, Cambridge, United Kingdom, July 14-18, 2002 (Chapman, S., Perham, R., Scrutton, N., eds.), 857-862 (2002)

[36]     On the enzymatic mechanism of lumazine synthase.
W. Meining, X. Zhang, M. Fischer, A. Bacher and R. Ladenstein.
Acta Cryst. (2002). A58 (Supplement), C107
[35]     Biofunctionalization of Surfaces: The Novel Protein Lumazine-Synthase
K. Sengupta, M. Tristl, M. Fischer and E. Sackmann
Biophys. J. 82 (1): 2719 Part 2 JAN (2002)

 

 

2001


[34]     Synthesis of nanophase iron oxide in lumazine synthase capsids
W. Shenton, S. Mann, H. Cölfen, A. Bacher and M. Fischer
Angew. Chem., Int. Ed. 40(2), 442-445 (2001)
[33]     Biosynthesis of riboflavin
A. Bacher, S. Eberhardt, W. Eisenreich, M. Fischer, S. Herz, B. Illarionov, K. Kis and G. Richter
Vitamins and Hormones (T. Begley, Ed.) Vol. 61, 1-49, Academic Press (2001)
[32]     X-Ray structure analysis and crystallographic refinement of lumazine synthase from the hyperthermophile Aquifex aeolicus at 1.6 Å resolution: Determination of thermostability revealed from structural comparison
X. Zhang, W. Meining, M. Fischer, A. Bacher and R. Ladenstein
J. Mol. Biol. 306(5), 1099-1114 (2001)
[31]     19F NMR ligand perturbation studies on 6,7-bis(trifluoromethyl)-8-ribityllumazine-7-hydrates and the lumazine synthase complex of Bacillus subtilis. Site-directed mutagenesis changes the mechanism and the stereoselectivity of the catalysed haloform-type reaction
J. Scheuring, K. Kugelbrey, S. Weinkauf, M. Cushman, A. Bacher and M. Fischer*
J. Org. Chem. 66(11), 3811-3819 (2001)
[30]     A method for soluble overexpression of the 7 nicotinic acetylcholine receptor extracellular domain
M. Fischer, P.-J. Corringer, K. Schott, A. Bacher and J.-P. Changeux
Proc. Natl. Acad. Sci. USA 98(6), 3567-3570 (2001)
[29]     Design of biofunctional assemblies on solids through recombinant spherical bacterial protein lumazine synthase
M. Fischer, A. Bacher, I. Haase, M. Tristl and E. Sackmann
Chem. Phys. Chem. 2, 623-627 (2001)
[28]     Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP
G. Bader, S. Schiffmann, A. Herrmann, M. Fischer, M. Gütlich, G. Auerbach, T. Ploom, A. Bacher, R. Huber and T. Lemm
J. Mol. Biol. 312(5), 1051-1057 (2001)

[27]     The NMR structure of the 47 kDa dimeric enzyme 3,4-dihydroxy-2-butanone 4-phosphate synthase and ligand binding studies reveal the location of the active site
M. J. S. Kelly, L. J. Ball, C. Krieger, Y. Yu, M. Fischer, S. Schiffmann, P. Schmieder, R. Kühne, W. Bermel, A. Bacher, G. Richter and H. Oschkinat
Proc. Natl. Acad. Sci. USA 98(23), 13025-13030 (2001)

 

 

2000


[26]     Electron microscopic observations on protein crystallization: adsorption layers, aggregates and crystal defects
N. Braun, J. Tack, M. Fischer, A. Bacher, L. Bachmann and S. Weinkauf
 J. Crystal Growth 212, 270-282 (2000)
[25]     Biosynthesis of terpenoids: 4-Diphosphocytidyl-2-C-methyl-D-erythritol kinase from tomato
F. Rohdich, J. Wungsitaweekul, H. Lüttgen, M. Fischer, W. Eisenreich, C. A. Schuhr, M. Fellermeier, N. Schramek, M. H. Zenk and A. Bacher
 Proc. Natl. Acid. Sci. US 97(15), 8251-8256 (2000)
[24]     The atomic structure of the pentameric lumazine synthase from Saccharomyces cerevisiae at 1.85 Å resolution reveals the binding mode of a phosphonate intermediate analogue
W. Meining, S. Mörtl, M. Fischer, M. Cushman, A. Bacher and R. Ladenstein
 J. Mol. Biol. 299(1), 181-197 (2000)
[23]     Zinc plays a key role in human and bacterial GTP cyclohydrolase I
G. Auerbach, A. Herrmann, A. Bracher, G. Bader, M. Gütlich, M. Fischer, M. Neukamm, M. Garrido-Franco, J. Richardson, H. Nar, R. Huber and A. Bacher
 Proc. Natl. Acad. Sci. US 97(25), 13567-13572 (2000)

[22]     Biosynthesis of vitamin B2
A. Bacher, S. Eberhardt, M. Fischer, K. Kis and G. Richter
 Annu. Rev. Nutr. 20, 153-67 (2000)

 

 

1999


[21]     Complementation of the fol2 deletion in Saccharomyces cerevisiae by human and Escherichia coli genes encoding GTP cyclohydrolase I
R. Mancini, F. Saracino, G. Buscemi, M. Fischer, N. Schramek, A. Bracher, A. Bacher, M. Gütlich and M. L. Agostoni Carbone
 Biochem. Biophys. Res. Commun. 255(2), 521-527 (1999)
[20]     Histidine 179 mutants of GTP cyclohydrolase I catalyze the formation of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone triphosphate
A. Bracher, M. Fischer, W. Eisenreich, H. Ritz, N. Schramek, P. Boyle, P. Gentili, R. Huber, H. Nar, G. Auerbach and A. Bacher
 J. Biol. Chem. 274(24), 16727-16735 (1999)
[19]     Investigation of the binding of fluorolumazines to the 1-MDa capsid of lumazine synthase by 15N{19F} REDOR NMR
J. M. Goetz, B. Poliks, D. R. Studelska, M. Fischer, K. Kugelbrey, A. Bacher, M. Cushman and J. Schäfer
 J. Amer. Chem. Soc. 121, 7500-7508 (1999)

 

[18]     Investigation of the Binding of 6,7-bis(trifluoromethyl)-8-ribityllumazines to 15N-labeled Lumazine Synthase by REDOR-NMR
M. Fischer, J. M. Goetz, B. Poliks, D. R. Studelska, A. Gießauf, K. Kugelbrey, M. Cushman and J. Schaefer
Flavins and Flavoproteins (Ghisla, S., ed.), 829-832 (1999)
[17]     19F NMR Studies on Lumazine Synthase from Bacillus subtilis
M. Fischer, K. Kugelbrey, J. Scheuring and M. Cushman
Flavins and Flavoproteins (Ghisla, S., ed.), 809-812 (1999)

 

 

1998


[16]     Evidence for local 32 symmetry in homotrimeric riboflavin synthase of Escherichia coli
W. Meining, G. Tibbelin, S. Eberhardt, M. Fischer, A. Bacher and R. Ladenstein
 J. Struct. Biol. 121(1), 53-60 (1998)

 

 

1997


[15]     Biosynthesis of riboflavin: GTP Cyclohydrolase II, deaminase and reductase
A. Bacher, G. Richter, H. Ritz, S. Eberhardt, M. Fischer and C. Krieger
 Methods Enzymol. 280, 382-389 (1997)

 

[14]     Biosynthesis of riboflavin: Lumazine synthase and riboflavin synthase
A. Bacher, S. Eberhardt, M. Fischer, S. Mörtl, K. Kis, K. Kugelbrey, J. Scheuring and K. Schott
 Methods Enzymol. 280, 389-399 (1997)
 

[13]     Biosynthesis of riboflavin. Characterization of the bifunctional deaminase/reductase of Escherichia coli and Bacillus subtilis.
G. Richter, M. Fischer, C. Krieger, S. Eberhardt, H. Lüttgen, I. Gerstenschläger and A. Bacher
 J. Bacteriol. 179(6), 2022-2028 (1997)
[12]     Studies on the NusB protein of Escherichia coli. Expression and determination of secondary-structure elements by multinuclear NMR spectroscopy
F. Berglechner, G. Richter, M. Fischer, A Bacher, R. M. Gschwind, M. Huenges, G. Gemmecker and H. Kessler
Eur. J. Biochem. 248(2), 338-346 (1997)
[11]     1.25 Å Crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters
G. Auerbach, A. Herrmann, M. Gütlich, M. Fischer, U. Jacob, A. Bacher and R. Huber
 EMBO J. 16(24), 7219-7230 (1997)

 

[10]     The crystal structure of mouse sepiapterin reductase
G. Auerbach, R. Huber, A. Herrmann, M. Gütlich, M. Fischer and A. Bacher
Chemistry and Biology of Pteridines and Folates (W. Pfleiderer, H. Rokos, eds.) pp. 591-594, Blackwell Wissenschafts-Verlag, Berlin, Vienna (1997)
[9]     GTP Cyclohydrolase I in developing chicken embryonic retina
M. Gütlich, M. Fischer, D. Cahill, A. Bacher, V. Holdengreber, M. Vechoropoulos, Y. Ben-Shaul and K. Witter
Chemistry and Biology of Pteridines and Folates (W. Pfleiderer, H. Rokos, eds.) pp. 607-610, Blackwell Wissenschafts-Verlag, Berlin, Vienna (1997)
[8]     Heterologous expression of recombinant human GTP cyclohydrolase I
M. Fischer, A. Bracher, R. Lutz, A. Herrmann, G. Auerbach, S. Grüneberg, R. Huber, F. Lottspeich, A. Bacher and M. Gütlich
Chemistry and Biology of Pteridines and Folates (W. Pfleiderer, H. Rokos, eds.) pp. 611-614, Blackwell Wissenschafts-Verlag, Berlin, Vienna (1997)
[7]     Expression, purification and characterization of murine sepiapterin reductase
A. Herrmann, M. Gütlich, M. Fischer, A. Bacher and M. Eulitz
Chemistry and Biology of Pteridines and Folates (W. Pfleiderer, H. Rokos, eds.) pp. 643-646, Blackwell Wissenschafts-Verlag, Berlin, Vienna (1997)

 

 

1996


[6]     NMR analysis of site-specific binding in oligomeric proteins. Dynamic studies on the interaction of riboflavin synthase with trifluoromethyl-substituted intermediates.
J. Scheuring, M. Fischer, M. Cushman, J. Lee, A. Bacher and H. Oschkinat
 Biochemistry 35(30), 9637-9646 (1996)
[5]     Biosynthesis of riboflavin. Lumazine synthase of Escherichia coli.
S. Mörtl, M. Fischer, G. Richter, J. Tack, S. Weinkauf and A. Bacher
 J. Biol. Chem. 271(52), 33201-33207 (1996)
[4]     Biosynthesis of riboflavin. Structure and mechanism of lumazine synthase
A. Bacher, M. Fischer, K. Kis, K. Kugelbrey, S. Mörtl, J. Scheuring, S. Weinkauf, S. Eberhardt, K. Schmidt-Bäse, R. Huber, K. Ritsert, M. Cushman and R. Ladenstein
Biochemical Society Transactions 24, 89-94 (1996)

 

[3]     Biosynthesis of riboflavin. Bifunctional pyrimidine deaminase/reductase of Escherichia coli and Bacillus subtilis
M. Fischer, S. Eberhardt, G. Richter, C. Krieger, I. Gerstenschläger and A. Bacher
Biochemical Society Transactions 24, 35S (1996)

[2]     Structure and mechanism of GTP cyclohydrolase I of Escherichia coli
H. Nar, R. Huber, W. Meining, A. Bracher, M. Fischer, C. Hösl, H. Ritz, C. Schmid, S. Weinkauf and A. Bacher
Biochemical Society Transactions 24, 37S (1996)
 

 

1995

 

[1]     Active site topology and reaction mechanism of GTP cyclohydrolase I.
H. Nar, R. Huber, G. Auerbach, M. Fischer, C. Hösl, H. Ritz, A. Bracher, W. Meining, S. Eberhardt and A. Bacher
 Proc. Natl. Acad. Sci. US 92(26), 12120-12125 (1995)

 

 

 

Aif Projects

  1. Forschungsvorhaben AiF 14338 N

  2. Forschungsvorhaben AiF 14387 N